Neoantigen-Specific T Cells in Adoptive Cell Therapy
Eric Tran
Abstract
ABSTRACT: The holy grail of cancer therapeutics is the destruction of cancer cells while avoiding harm to normal cells. Cancer is unique from normal tissues because of the presence of somatic mutations that accumulate during tumorigenesis. Some nonsynonymous mutations can give rise to mutated peptide antigens (hereafter referred to as neoantigens) that can be specifically recognized by T cells. Thus, the immunological targeting of neoantigens represents a safe and promising strategy to treat patients with cancer. This article reviews the clinical application of adoptive cell therapy targeting neoantigens in patients with epithelial cancers.
Topics & Concepts
Adoptive cell transferCell therapyMedicineImmunologyT cellCellChemistryImmune systemBiochemistryCAR-T cell therapy researchImmunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies Research