Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction
Jialei Li, Yu Han, Shuang Wang, Xiaolei Wu, Ji‐Min Cao, Teng Sun
Abstract
Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined. Circular RNAs (circRNAs) are widely believed to participate in cardiac pathologic processes, especially in myocardial infarction. In this review, we round up the biogenesis of circRNAs, briefly describe their biological functions, and summarize the latest literature on multifarious circRNAs related to new therapies and biomarkers for myocardial infarction.
Topics & Concepts
BiogenesisCircular RNAmicroRNAMyocardial infarctionComputational biologyBiologyNon-coding RNABioinformaticsFunction (biology)MedicineCardiologyGeneticsGeneCircular RNAs in diseasesMicroRNA in disease regulation