Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model
Mengmeng Ma, Zhenqi Liu, Nan Gao, Zifeng Pi, Xiubo Du, Jinsong Ren, Xiaogang Qu
Abstract
O@EM-K shows no apparent toxicity in 3xTg-AD mice. Overall, this work provides an example for developing biocompatible and synergistic clearance of peripheral Aβ associated with AD.
Topics & Concepts
ChemistryAmyloid (mycology)BiophysicsBlood–brain barrierMembraneIn vivoBiocompatibilityPharmacologyBiochemistryNeuroscienceCentral nervous systemMedicineBiotechnologyInorganic chemistryOrganic chemistryBiologyAdvanced Nanomaterials in CatalysisNanocluster Synthesis and ApplicationsAlzheimer's disease research and treatments