Cell‐free DNA methylation‐based preeclampsia prediction: A journey to improve maternal health
Mio Aerden, Marie De Borre, Bernard Thienpont
Abstract
Presymptomatic prediction of preeclampsia (PE) is crucial to enable early prophylactic treatment. Current screening tools are either complex or lack predictive value. We recently demonstrated that cell-free DNA methylation can be leveraged to predict early-onset PE in 57% at a 10% false positive rate. Importantly, this minimally invasive screening test can be implemented as an add-on to current widespread noninvasive prenatal aneuploidy screening. Here, we highlight the pitfalls and promising prospects of this research.
Topics & Concepts
Cell-free fetal DNAPreeclampsiaPredictive valueDNA methylationAneuploidyMedicinePrenatal diagnosisPrenatal screeningObstetricsPregnancyBioinformaticsComputational biologyOncologyBiologyInternal medicineFetusGeneticsGeneChromosomeGene expressionPregnancy and preeclampsia studiesPrenatal Screening and DiagnosticsGestational Diabetes Research and Management