Design, synthesis, and anticancer assessment of structural analogues of (<i>E</i>)-1-((3,4,5-trimethoxybenzylidene)amino)-4-(3,4,5-trimethoxyphenyl)imidazo[1,2-<i>a</i>]quinoxaline-2-carbonitrile (6b), an imidazo[1,2-<i>a</i>]quinoxaline-based non-covalent EGFR inhibitor
Manvendra Kumar, Kiran T. Patil, Pritam Maity, Joydeep Chatterjee, Tashvinder Singh, Gaurav Joshi, Sandeep K. Singh, Raj Kumar
Abstract
Two lead compounds, 5a and 5l, designed on an imidazo[1,2- a ]quinoxaline template, emerged as potent EGFR inhibitors and anti-lung cancer agents.
Topics & Concepts
QuinoxalineChemistryCombinatorial chemistryStereochemistryPharmacologyBiologyOrganic chemistrySynthesis and Biological EvaluationQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms