Rapid Synthesis of Luotonin A Derivatives via Synergistic Visible-Light Photoredox and Acid Catalysis
Feng Wu, Wuheng Dong, Sijie Fan, Yao Yuan, Caiyun Liang, Aiyu Chen, Zuodong Yin, Zhaoguo Zhang
Abstract
The merging of visible-light photoredox and acid catalysis allowed for an intramolecular Povarov cycloaddition reaction using eosin Y as the photocatalyst and TsOH·H2O as the co-catalyst. A visible-light-promoted dehydrogenative cyclization protocol enabled the construction of Luotonin A derivatives with up to 97% yield.
Topics & Concepts
Photoredox catalysisEosin YVisible spectrumCatalysisPhotocatalysisPhotochemistryChemistryIntramolecular forceCycloadditionYield (engineering)Combinatorial chemistryOrganic chemistryMaterials scienceOptoelectronicsMetallurgyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions