Long-term light and moderate exercise intervention similarly prevent both hippocampal and glycemic dysfunction in presymptomatic type 2 diabetic rats
Subrina Jesmin, Takeru Shima, Mariko Soya, Kanako Takahashi, Omura Koki, Kasane Ogura, Hikaru Koizumi, Hideaki Soya
Abstract
Type 2 diabetes mellitus is an independent risk factor for hippocampal memory dysfunction, which would progress since the prediabetic stage. We found that 4 mo of exercise both at the light and moderate intensity prevented the progression of memory dysfunction with an improvement of hippocampal MCT2 expression in presymptomatic diabetes, implying that light intensity exercise could be a therapeutic approach, and the alteration of hippocampal MCT2 would be a therapeutic target of memory dysfunction from presymptomatic diabetes.
Topics & Concepts
Hippocampal formationMedicineDiabetes mellitusGlycemicInternal medicineType 2 diabetesType 2 Diabetes MellitusEndocrinologyNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms