Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity
Xuan Zhang, Dinesh Thummuri, Xingui Liu, Wanyi Hu, Peiyi Zhang, Sajid Khan, Yaxia Yuan, Daohong Zhou, Guangrong Zheng
Topics & Concepts
ChemistryPlateletCancer cellBcl-xLToxicityPharmacologyCancer researchCancerApoptosisProgrammed cell deathBiochemistryBiologyImmunologyGeneticsOrganic chemistryProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways