Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4
Amandeep Girdhar, Vidhya Bharathi, Vikas Tiwari, Suman Abhishek, Waghela Deeksha, Usha Mahawar, Gembali Raju, Sandeep K. Singh, Ganesan Prabusankar, Eerappa Rajakumara, Basant K. Patel
Topics & Concepts
Isothermal titration calorimetryIn vitroChemistryRNAProtein aggregationSmall moleculeBiophysicsBinding siteStress granuleBiochemistryCell biologyBiologyTranslation (biology)GeneMessenger RNAAmyotrophic Lateral Sclerosis ResearchRNA Research and SplicingPrion Diseases and Protein Misfolding