NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice
Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J. Ulevitch, Jiahuai Han
Abstract
-caused mice death is attenuated by blocking these death pathways. Thus, to reduce the lethality of infection-related diseases, preventing cell death might be necessary when propagation of infected pathogen was controlled by other means.
Topics & Concepts
InflammasomeLethalityNLRC4Programmed cell deathCell biologyBiologyPyroptosisInflammationApoptosisCancer researchCaspase 1ImmunologyGeneticsInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxidePhagocytosis and Immune Regulation