Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation
Saltanat Ualiyeva, Evan Lemire, Evelyn C. Avilés, Caitlin Wong, Amelia Boyd, Juying Lai, Tao Liu, Ichiro Matsumoto, Nora A. Barrett, Joshua A. Boyce, Adam L. Haber, Lora G. Bankova
Abstract
; this effect was further enhanced by concomitant blockade of IL-25. Our findings identified a potent synergy of CysLTs and IL-25 downstream of aeroallergen-trigged activation of airway tuft cells leading to a highly polarized type 2 immune response and further implicate airway tuft cells as powerful modulators of type 2 immunity in the lungs.
Topics & Concepts
InflammationImmunologyLungTuftBiologyMedicineInternal medicineComposite materialMaterials scienceIL-33, ST2, and ILC PathwaysAsthma and respiratory diseasesEosinophilic Esophagitis