TET-mediated 5-methylcytosine oxidation in tRNA promotes translation
Hui Shen, Robert Jordan Ontiveros, Michael C. Owens, Monica Yun Liu, Uday Ghanty, Rahul M. Kohli, Kathy Fange Liu
Abstract
C oxidation in tRNA promotes translation in vitro. These results suggest TET2 may influence translation through impacting tRNA methylation and reveal an unexpected role for TET enzymes in regulating multiple nodes of the central dogma.
Topics & Concepts
Transfer RNATranslation (biology)5-MethylcytosineChemistryBiochemistryComputational biologyBiologyRNADNA methylationMessenger RNAGeneGene expressionRNA modifications and cancerEpigenetics and DNA MethylationCancer-related gene regulation