<i>C9orf72</i> poly(GR) aggregation induces TDP-43 proteinopathy
Casey Cook, Yanwei Wu, Hana M. Odeh, Tania F. Gendron, Karen Jansen‐West, Giulia del Rosso, Mei Yue, Peizhou Jiang, Edward Gomes, Jimei Tong, Lillian M. Daughrity, Nicole M. Avendano, Monica Castanedes‐Casey, Wei Shao, Björn Oskarsson, Giulio Srubek Tomassy, Alexander McCampbell, Frank Rigo, Dennis W. Dickson, James Shorter, Yong‐Jie Zhang, Leonard Petrucelli
Abstract
-targeted therapeutics reduce TDP-43 pathology in vivo, and demonstrate that alterations in plasma NFL provide insight into the therapeutic efficacy of disease-modifying treatments.
Topics & Concepts
In vitroIn vivoCell biologyKey (lock)ChemistryBiophysicsBiologyBiochemistryGeneticsEcologyAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchHeterotopic Ossification and Related Conditions