CCR7 expression in CD19 chimeric antigen receptor-engineered natural killer cells improves migration toward CCL19-expressing lymphoma cells and increases tumor control in mice with human lymphoma
Nathan Thomas Schomer, Ziyue Karen Jiang, Marit I. Lloyd, Hans Klingemann, Laurent Boissel
Topics & Concepts
CCL19C-C chemokine receptor type 7NKG2DCancer researchChimeric antigen receptorInterleukin 21Cytotoxic T cellImmunologyBiologyT cellMolecular biologyImmune systemChemokine receptorChemokineIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionLymphoma Diagnosis and Treatment