Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment
Yang Hu, Margareta Hammarlund‐Udenaes
Abstract
than to improve the ability of the NC to cross the BBB in its intact form. Brain-targeted NCs, which are mostly developed for treating brain tumors, including metastases, should aim to enhance drug delivery not just to tumor regions with disrupted BBB, but equally important to regions with intact BBB where the drugs themselves have problems reaching. This article provides critical insights into how a brain-targeted nanoformulation needs to be designed and optimized to achieve therapeutic success in the brain.
Topics & Concepts
NanocarriersDrugPharmacologyMedicinePharmacokineticsBlood–brain barrierDrug deliveryDrug delivery to the brainNeuroscienceChemistryCentral nervous systemPsychologyInternal medicineOrganic chemistryNanoparticle-Based Drug DeliveryGlioma Diagnosis and TreatmentNanoplatforms for cancer theranostics