Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death
Bo Yan, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai
Topics & Concepts
DephosphorylationPhosphodiesteraseCyclic guanosine monophosphateCell biologyBiologyProgrammed cell deathSecond messenger systemChemistryBiochemistryPhosphorylationSignal transductionApoptosisEnzymePhosphataseEndocrinologyNitric oxidePhosphodiesterase function and regulationReceptor Mechanisms and SignalingCholinesterase and Neurodegenerative Diseases