Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in <i>Polg</i> <sup>D257A</sup> mice
Esther W. Lim, Michal K. Handzlik, Elijah Trefts, Jivani M. Gengatharan, Carlos M. Pondevida, Reuben J. Shaw, Christian M. Metallo
Abstract
mice exhibited thermal hypoalgesia. These results highlight the longitudinal changes that occur in intermediary metabolism upon mitochondrial impairment and identify a contributing mechanism to mitochondria-associated neuropathy.
Topics & Concepts
Peripheral neuropathyPeripheralLipid metabolismAlanineMetabolismMitochondrionAmino acidEndocrinologyInternal medicineMedicineBiochemistryBiologyChemistryDiabetes mellitusMitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseBiochemical Acid Research Studies