The SARAH trial: more evidence on the role of neurohormonal blockers in prevention of anthracycline-induced cardiotoxicity
Albulena Mecinaj, Victoria Vinje-Jakobsen, D. Ngo, Aaron L. Sverdlov, Peder L. Myhre
Abstract
This mini-review highlights the results of the SARAH trial, which evaluated the efficacy of sacubitril/valsartan in preventing subclinical cardiac dysfunction in patients undergoing anthracycline-based chemotherapy. The trial demonstrated a significant reduction in GLS decline in the treatment group compared to placebo. The findings are discussed in context with other trials investigating neurohormonal blockade for the prevention of cancer therapy-related cardiac dysfunction.
Topics & Concepts
MedicineCardiotoxicityAnthracyclineValsartanContext (archaeology)Heart failureSubclinical infectionPlaceboInternal medicineChemotherapySacubitril, ValsartanBlockadeCardiologyIntensive care medicineOncologyCancerAlternative medicineBreast cancerBlood pressureBiologyReceptorPaleontologyPathologyChemotherapy-induced cardiotoxicity and mitigationCancer-related cognitive impairment studiesCancer Treatment and Pharmacology