Conformational dynamics and kinetics of protein interactions by nuclear magnetic resonance
Adolfo H. Moraes, Ana Paula Valente
Abstract
Structural information of protein complexes is fundamental for the rational drug design and improvement of vaccines and biosensors. Also, protein misassembly can have severe biological consequences. Here we discuss the challenges of studying protein complexes and show examples of systems characterized using NMR.
Topics & Concepts
KineticsDynamics (music)Rational designProtein dynamicsBiophysicsChemistryProtein structureBiosensorNuclear magnetic resonanceBiological systemNanotechnologyChemical physicsMaterials scienceBiochemistryPhysicsBiologyAcousticsQuantum mechanicsProtein Structure and DynamicsEnzyme Structure and FunctionRNA and protein synthesis mechanisms