Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias
Yifei Yang, Yonghai Wang, Aixia Zuo, Chunmei Li, Wenyan Wang, Wanglin Jiang, Xiaochen Zhang, Xin Che, Yang Zhang, Wentao Wu, Xiaobo Cen, Hongbo Wang, Jingwei Tian
Topics & Concepts
ChemistryFunctional selectivityPharmacologyIntrinsic activityAgonistReceptorOpioidSignal transductionμ-opioid receptorAnalgesicStereochemistryAdverse effectG protein-coupled receptorBiochemistryMedicineReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects