Autoimmune Pericarditis: Diagnosis and New Therapeutics
Heba Wassif, Elizabeth Ghandakly, Habib Layoun, Jaideep Singh Bhalla, Emily Littlejohn, Tom Kai Ming Wang, M. Elaine Husni, Allan Klein
Abstract
PURPOSE OF REVIEW: To provide an overview of the diagnosis and updated therapeutic approach to autoimmune pericarditis. RECENT FINDINGS: Subtypes of autoimmune pericarditis may benefit from IL-1 inhibition and future phenotyping based on clinical presentation, biomarkers, and imaging may aid in guiding future therapeutic approaches. Autoimmune pericarditis is a unique phenotype of pericarditis for which there is scarce data. The clinical spectrum of pericardial involvement associated with autoimmune disorders varies in acuity, recurrence, severity, and symptomatic presentation. There is a pathophysiologic distinction that separates autoimmune and autoinflammatory pericarditis from other pericarditis presentations. This review explores the state of the art in diagnosis and therapeutic management.