Litcius/Paper detail

Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium

Yu Zhong, Kabhilan Mohan, Jinpeng Liu, Ahmad Al‐Attar, Penghui Lin, Robert M Flight, Qiushi Sun, Marc O. Warmoes, Rahul Deshpande, Huijuan Liu, Kyung Sik Jung, Mihail I. Mitov, Nianwei Lin, D. Allan Butterfield, Shuyan Lu, Jinze Liu, Hunter Moseley, Teresa W.‐M. Fan, Mark E. Kleinman, Qing Jun Wang

2020Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease43 citationsDOIOpen Access PDF

Topics & Concepts

Batten diseaseAutophagyBiologyLipofuscinRetinal pigment epitheliumNeuronal ceroid lipofuscinosisRetinal degenerationTFEBCell biologyNeurodegenerationmTORC1RetinalEndocrinologyInternal medicineProtein kinase BBiochemistryMedicineGeneDiseasePhosphorylationApoptosisLysosomal Storage Disorders ResearchAutophagy in Disease and TherapyRetinal Diseases and Treatments