Neural lineage differentiation of human pluripotent stem cells: Advances in disease modeling
Yuan-Wei Yan, Eddie S. Qian, Lauren E. Woodard, Julie Bejoy
Abstract
the directed differentiation of human pluripotent stem cells (hPSCs) to neural lineages including neurons, astrocytes, and oligodendrocytes. Three-dimensional models such as brain organoids have also been derived from hPSCs, offering more physiological relevance due to their incorporation of various cell types. As such, brain organoids can better model the pathophysiology of neural diseases observed in patients. In this review, we will emphasize recent developments in hPSC-based tissue culture models of neurological disorders and how they are being used to create neural disease models.
Topics & Concepts
Induced pluripotent stem cellNeuroscienceHuman Induced Pluripotent Stem CellsDiseaseHuman brainNeural stem cellOrganoidMedicineStroke (engine)BiologyStem cellEmbryonic stem cellPathologyCell biologyBiochemistryGeneMechanical engineeringEngineeringPluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms3D Printing in Biomedical Research