Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis
Yifan Wu, Jiahao Ying, Xiaoyan Zhu, Chen-Qin Xu, Long Wu
Topics & Concepts
ChemistryNitric oxideInflammationNitric oxide synthaseIn vivoSignal transductionMatrix metalloproteinaseTumor necrosis factor alphaNF-κBAggrecanPharmacologyOsteoarthritisCell biologyBiochemistryBiologyImmunologyMedicinePathologyOrganic chemistryAlternative medicineBiotechnologyArticular cartilageNatural product bioactivities and synthesisMedicinal plant effects and applicationsBiological Activity of Diterpenoids and Biflavonoids