Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To Mediate Protection from Influenza Virus Challenge
Sean A. Nelson, Thamotharampillai Dileepan, Amy Rasley, Marc K. Jenkins, Nicholas O. Fischer, Andrea J. Sant
Abstract
Exploiting new, more efficacious strategies to potentiate influenza virus-specific immune responses is important, particularly for at-risk populations. We have demonstrated the promise of direct intranasal protein vaccination to establish long-lived immunity in the lung with CD4 T cells that possess features and positioning in the lung that are associated with both immediate and long-term immunity, as well as demonstrating direct protective potential.
Topics & Concepts
VaccinationImmunologyVirologyBiologyInfluenza A virusHemagglutinin (influenza)VirusImmunityAntigenImmune systemCytotoxic T cellT cellIn vitroBiochemistryInfluenza Virus Research StudiesImmune Response and InflammationImmune Cell Function and Interaction