Cu-Catalyzed α-Alkylation of Glycine Derivatives for C(sp<sup>3</sup>)–H/C(sp<sup>3</sup>)–H Bond Selective Functionalization
Huan Xiang, Yang Ye
Abstract
Herein, we present the example of Cu-catalyzed oxidation coupling of amino acids/peptides for producing α-alkylated unnatural glycine derivatives by the activation of double C(sp 3 )–H/C(sp 3 )–H bonds. It is worth mentioning that the tractable conditions and good functional group tolerance allow the specific site-modification of polypeptides utilizing this strategy. The practicality of this transformation is certified by the potent preparation of a series of HDAC inhibitors (SPACAs), which performed well in the preliminary biological evaluations. A radical–radical coupling pathway was involved in the reaction based on the preliminary mechanistic studies.
Topics & Concepts
AlkylationChemistryCatalysisGlycineSurface modificationFunctional groupCombinatorial chemistryStereochemistryCoupling reactionAmino acidMedicinal chemistryOrganic chemistryBiochemistryPolymerPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis