Spectroscopic Evidence for a Cobalt-Bound Peroxyhemiacetal Intermediate
Yeongjin Son, Kyungmin Kim, S.C. Kim, Guilherme L. Tripodi, Aleksandr Y. Pereverzev, Jana Roithová, Jaeheung Cho
Abstract
, whereas the reaction with acyl chlorides proceeds by a nucleophilic attack. The observation of the peroxyhemiacetal intermediate provides significant insight into the initial step of aldehyde deformylation by metalloenzymes.
Topics & Concepts
AldehydeChemistryCobaltReactivity (psychology)AdductNucleophileReaction intermediateReaction mechanismMetalKinetic isotope effectPhotochemistryMedicinal chemistryOrganic chemistryCatalysisQuantum mechanicsPathologyPhysicsDeuteriumAlternative medicineMedicineMetal-Catalyzed Oxygenation MechanismsMetal complexes synthesis and propertiesPorphyrin Metabolism and Disorders