Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors
Pei Chen, Huachao Bin, Yan Jiao, Guifeng Lin, Yun Zhang, Anjie Xia, Zhilin Pan, Jingxin Qiao, Yinping Guo, Jingming Liu, Yangli Zhou, Linli Li
Topics & Concepts
ChemistryKinaseDrug discoveryPyrimidinePhosphorylationDNA damageIn vitroBiochemistryDNADNA Repair MechanismsCancer therapeutics and mechanismsCell death mechanisms and regulation