CK1δ as a potential therapeutic target to treat bladder cancer
Yu‐Chen Lin, Mei-Chuan Chen, Tsung‐Han Hsieh, Jing‐Ping Liou, Chun‐Han Chen
Abstract
gene, which codes for CK1δ, is upregulated in superficial and infiltrating bladder cancer patients in two independent datasets. CK1δ knockdown decreased β-catenin expression in bladder cancer cells and inhibited their growth. Additionally, 13i HCl suppressed bladder cancer cell proliferation and increased apoptosis. We also observed that inhibition of CK1δ using 13i HCl or PF-670462 triggers necroptosis in bladder cancer cells. Finally, 13i HCl inhibited bladder cancer cell migration and reversed their mesenchymal characteristics. These findings suggest further development of 13i HCl as a potential therapeutic agent to treat bladder cancer is warranted.
Topics & Concepts
Bladder cancerMedicineCancerInternal medicineWnt/β-catenin signaling in development and cancerCancer-related gene regulationEpigenetics and DNA Methylation