Long-term fucoxanthin treatment prevents cognitive impairments and neuroinflammation <i>via</i> the inhibition of Nogo-A in APP/PS1 transgenic mice
Yujie Jiang, Huiyue Chen, Jiayi Xu, Jingyang Le, Wenni Rong, Zengyu Zhu, Yuan Chen, Chenwei Hu, Jinhan Cai, Yirui Hong, Shangwei Huang, Meilin Zheng, Xinyu Zhang, Chenhui Zhou, Jinrong Zhang, Shan He, Xiaojun Yan, Wei Cui
Abstract
the inhibition of Nogo-A. These results not only elucidate an anti-neuroinflammatory mechanism of fucoxanthin, but also provide strong support for the development of fucoxanthin as a novel food ingredient or drug for the treatment of AD.
Topics & Concepts
NeuroinflammationFucoxanthinCognitionNeuroscienceGenetically modified mouseTransgeneMedicineDiseasePsychologyBiologyInternal medicineCarotenoidBiochemistryGeneSeaweed-derived Bioactive CompoundsEchinoderm biology and ecology