Formulation and evaluation of fast dissolving tablets of haloperidol solid dispersion
Aya M. Eisa, Nagia A. El-Megrab, Hanan M. El-Nahas
Abstract
Purpose: The aim of this study was to design fast dissolving tablets (FDT) of the anti -psychiatric drug haloperidol in solid dispersion forms as a way to enhance its dissolution profile and anti-psychiatric effect. Methods: studies through forced swimming test (FST). Results: study of (SD2) formulation revealed the highest immobility time to rats compared to control rats and others treated with commercial haloperidol product. Conclusion: Fast dissolving tablets prepared from solid dispersion of haloperidol with PEG4000 expressed rapid onset of action with enhanced anti-psychiatric effect of haloperidol
Topics & Concepts
DissolutionHaloperidolDispersion (optics)Materials scienceChromatographyMedicineChemistryOpticsPhysicsInternal medicineOrganic chemistryDopamineDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsMicroencapsulation and Drying Processes