A dual-sensitive nanoparticle-mediated deepening synergistic therapy strategy involving DNA damage and ICD stimuli to treat triple-negative breast cancer
Shangui Liu, Xinru Kong, Yuelin Fang, HE Zhi-jing, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Abstract
. In this manner, the NPs could significantly inhibit primary tumor, abscopal tumor, pulmonary metastasis and recurrent tumor in a subcutaneous 4T1 tumor model, with effective biosafety. This study has provided a promising deepening synergistic therapy strategy against TNBC.
Topics & Concepts
Cancer researchTriple-negative breast cancerDoxorubicinChemistryPhotodynamic therapyHyaluronic acidTumor microenvironmentIn vivoDNA damageImmunogenic cell deathInternalizationBreast cancerApoptosisProgrammed cell deathCancerChemotherapyMedicineCellBiologyBiochemistryDNAInternal medicineTumor cellsBiotechnologyAnatomyOrganic chemistryNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesNanoparticle-Based Drug Delivery