New β-Lactam–β-Lactamase Inhibitor Combinations
Dafna Yahav, Christian G. Giske, Alise Grāmatniece, Henrietta Abodakpi, Vincent H. Tam, Leonard Leibovici
Abstract
The limited armamentarium against drug-resistant Gram-negative bacilli has led to the development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this review, we summarize their spectrum of in vitro activities, mechanisms of resistance, and pharmacokinetic-pharmacodynamic (PK-PD) characteristics. A summary of available clinical data is provided per drug. Four approved BLBLIs are discussed in detail. All are options for treating multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa .
Topics & Concepts
MeropenemCefepimeCeftazidime/avibactamAcinetobacter baumanniiPseudomonas aeruginosaKlebsiella pneumoniaeMicrobiologyImipenemCarbapenemMedicineBeta-Lactamase InhibitorsDrug resistanceAntibioticsBiologyCeftazidimeAntibiotic resistanceBacteriaEscherichia coliGeneGeneticsBiochemistryAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory Infections