Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity.
Joshua R. Huot, Fabrizio Pin, Andrea Bonetto
Abstract
muscle force, as well as MUNE were reduced in C26, MC38, HCT116 hosts, and in mice receiving folfiri and cisplatin compared to their respective experimental controls. In addition, MUNE was correlated with muscle force and muscle mass in all experimental conditions, while assessment of neuromuscular junction (NMJ) protein expression and changes in presynaptic morphology suggested that cancer and chemotherapy significantly alter muscle innervation. The present results demonstrate that the loss of motor unit connectivity may contribute to skeletal muscle wasting and weakness that occur with cancer and chemotherapy.
Topics & Concepts
CachexiaWastingMedicineSkeletal muscleCancerMuscle weaknessChemotherapyCisplatinMotor unitWeaknessIn vivoInternal medicineOncologyBiologySurgeryAnatomyBiotechnologyMuscle Physiology and DisordersNutrition and Health in AgingFibromyalgia and Chronic Fatigue Syndrome Research