High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders
Xiaoyu Peng, Yang Li, Junfeng Qu, Lizhi Jiang, Kaiyue Wu, Dan Liu, Yuping Chen, Junmei Peng, Canqing Yu, Xuan Cao
Topics & Concepts
ChemistryPARP1VeliparibSteric effectsWarheadPoly ADP ribose polymeraseDestabilisationCancer researchStereochemistryBiochemistryEnzymePolymeraseBiologyMedicineNursingAerospace engineeringEngineeringPARP inhibition in cancer therapyAdvancements in Semiconductor Devices and Circuit DesignIntegrated Circuits and Semiconductor Failure Analysis