Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities

Hesham A. M. Gomaa, Mohamed E. Shaker, Sami I. Alzarea, Omnia M. Hendawy, Fatma A. Mohamed, Ahmed M. Gouda, Asmaa T. Ali, Martha M. Morcoss, Mostafa Abdelrahman, Laurent Trembleau, Bahaa G. M. Youssif