Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity
Zhipeng Chen, Zhenzhen Fan, Xiaowei Dou, Qian Zhou, Guandi Zeng, Lu Liu, Wensheng Chen, Ruirui Lan, Wanting Liu, Guoqing Ru, Lei Yu, Qing‐Yu He, Liang Chen
Abstract
Combinational treatment with TAK1 inhibitor and MEK1/2 inhibitor effectively shrank Kras mutation positive and CLU deficient NSCLC tumors. Moreover, we put forward a concept that loss of function of a TSG rewires signaling network and thereby creates an Achilles' heel in tumor cells which could be exploited in precision medicine.
Topics & Concepts
ClusterinSuppressorCancer researchHyperactivationLung cancerNF-κBTumor suppressor geneSignal transductionGeneMedicineChemistryCell biologyCancerBiologyApoptosisCarcinogenesisPathologyInternal medicineGeneticsClusterin in disease pathologyBiomarkers in Disease MechanismsFerroptosis and cancer prognosis