Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D’Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina
Abstract
was found to be metabolically stable when incubated with human liver microsomes.
Topics & Concepts
ChemistryGPX4GlutathioneMalondialdehydeIn vivoGPX1BiochemistryMolecular biologyOxidative stressGlutathione peroxidaseEnzymeBiologyBiotechnologyFerroptosis and cancer prognosisCancer, Lipids, and MetabolismInflammatory mediators and NSAID effects