Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys
Julia Schrankl, Michaela Fuchs, Katharina A.E. Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner
Abstract
Angiotensin II (ANG II) type 1 (AT 1 ) receptors are essential for mediating the effects of ANG II in the kidneys. This study aimed to obtain a comprehensive overview about the cell-specific localization of AT 1 receptor expression in rodent and human kidneys using the novel RNAscope technique. We found that the conserved AT 1 receptor mRNA expression sites across species are the (juxta)glomerular areas and tubulointerstitium, which might present main target sites for ANG II in adult human and rodent kidneys.
Topics & Concepts
RodentReceptorAngiotensin IIBiologyRenin–angiotensin systemAngiotensin receptorKidneyGeneCell biologyMolecular biologyEndocrinologyInternal medicineMedicineGeneticsEcologyBlood pressureRenin-Angiotensin System StudiesHormonal Regulation and HypertensionReceptor Mechanisms and Signaling