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Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity

Liang Zhou, Guang‐Yu Lian, Tao Zhou, Zhe Cai, Shuai Yang, Weining Li, Lilin Cheng, Ye Ying, Mingfeng He, Jian Lu, Qifeng Deng, Bihui Huang, Xiaoqian Zhou, Desheng Lü, Feng Zhi, Jun Cui

2025Nature Cancer95 citationsDOI

Topics & Concepts

PalmitoylationImmunitySensitivity (control systems)ChemistryImmunologyBiologyImmune systemBiochemistryEngineeringElectronic engineeringEnzymeCysteineFerroptosis and cancer prognosisCancer-related molecular mechanisms researchRNA modifications and cancer
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity | Litcius