Oral contraceptives and colorectal cancer risk - A meta-analysis and systematic review
Fadi Abusal, Mohannad Aladwan, Yazan Alomari, Saja Obeidat, Salah Abuwardeh, Haya AlDahdouh, Qotada Al-Shami, Qusai Odat
Abstract
= 585.13, df = 6 (P < 0.00001). A test of the overall effect of ever use versus never use of oral contraceptives was Z = 21.85 (P < 0.00001). All the studies had a pooled risk ratio (RR) of 0.53. The use of oral contraceptives is associated with reduced risk of developing colorectal cancer. There is a need for further research into the biological mechanisms underlying these relationships, which may lead to insights into potential preventive interventions for colorectal carcinogenesis in women. The keywords used to locate studies included in this meta-analysis include Keywords targeting oral contraceptives included oral contraceptive pills, and birth control pills. Search keywords targeting colorectal carcinogenesis included neoplasms, tumors, or colon and rectal cancer.