Influences of alcohol/polyols on interaction of moxifloxacin hydrochloride through cetyltrimethylammonium bromide at numerous temperatures and compositions
Zahirul Islam Chowdhury, Javed Masood Khan, Shahed Rana, Shamim Mahbub, Farhad M. Hossain, Mohammad Majibur Rahman, Mohammad Irfan, Mohammad Z. Ahmed, Md. Anamul Hoque, Sk. Jahir Anwar
Abstract
A study on the interaction of a fourth-generation antibiotic drug, moxifloxacin hydrochloride (MFH), with a cationic surfactant, such as cetyltrimethylammonium bromide (CTAB) in the aqueous solution of alcohol (1-propanol (1-PrOH)) and polyols (galactose/maltose), has been carried out using the conductivity measurement technique. The critical micelle concentration (cmc), micelle ionisation (α), counter ion binding (β), and thermodynamic properties (ΔGm0, ΔHm0, and ΔSm0) for the self-aggregation of MFH + CTAB mixture have been estimated in 1-PrOH/polyols solutions. The presence of 1-PrOH delays the MFH + CTAB micelle formation, whereas polyols create a congenial environment for the micelle formation. In 1-PrOH, the values of α experience a reduction with the increase of 1-PrOH concentration and temperature. The values of α were found to be dependent on the concentration of other additives. In all of the cases thoroughly studied, the values of ΔGm0 were found negative, which experience an enhancement in polyols solutions and decreased in 1-PrOH solution. On the basis of ΔHm0 and ΔSm0 values, the suggested interaction forces between MFH and surfactant are hydrophobic, ion-dipole, and electrostatic in nature. The values of ΔHm0,∗ reveal that the micelle is more stable in polyols media than that of the 1-PrOH medium.