Comprehensive analyses of the inotropic compound omecamtiv mecarbil in rat and human cardiac preparations
Alexandra Rhoden, Thomas G. Schulze, Niels Pietsch, Torsten Christ, Arne Hansen, Thomas Eschenhagen
Abstract
We developed a novel setup allowing precise control of preload of EHT and characterized effects of the myosin activator OM. OM not only exerted contraction-slowing and positive inotropic effects but also increased diastolic tension. Effect size and direction varied between species, auxotonic and isometric conditions, concentration, and time. We also observed OM-induced increase of mitochondrial ROS, which has not been observed before and may explain part of the effects on contractility.
Topics & Concepts
InotropeMedicinePharmacologyCardiologyCardiac Ischemia and ReperfusionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research