Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice
Faeq Al‐Mudares, Manuel Cantu Gutierrez, Abiud Cantu, Weiwu Jiang, Lihua Wang, Xiaoyu Dong, Bhagavatula Moorthy, Enikö Sajti, Krithika Lingappan
2023American Journal of Physiology-Lung Cellular and Molecular Physiology11 citationsDOIOpen Access PDF
Abstract
We show for the first time that loss of Gdf15 exacerbates mortality, lung injury, and the phenotype of the arrest of alveolarization in the developing lung with loss of female-sex advantage in Gdf15 −/− mice. We also highlight the distinct pulmonary transcriptomic response in the Gdf15 −/− lung including pathways related to macrophage recruitment and activation.
Topics & Concepts
GDF15LungPhenotypeTranscriptomeBiologyMedicineInternal medicineImmunologyGene expressionGeneGeneticsGDF15 and Related BiomarkersNutrition and Health in AgingNeonatal Respiratory Health Research