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Electrocatalytic Ammonia Oxidation by Pyridyl-Substituted Ferrocenes

Md Estak Ahmed, Richard J. Staples, Thomas R. Cundari, Timothy H. Warren

2025Journal of the American Chemical Society26 citationsDOIOpen Access PDF

Abstract

High Resolution Image Download MS PowerPoint Slide Ammonia (NH 3 ) is a promising carbon-free fuel when prepared from sustainable resources. First-row transition metal electrocatalysts for ammonia oxidation are an enabling technology for sustainable energy production. We describe electrocatalytic ammonia oxidation using robust molecular complexes based on Earth-abundant iron. Electrochemical studies of ferrocenes with covalently attached pyridine arms reveal facile ammonia oxidation in DMSO (2.4 M NH 3 ) with modest overpotentials (η = 770–820 mV) and turnover frequencies (125–560 h –1 ). Experimental and computational studies indicate that the pendant pyridyl base serves as an H-bond acceptor with an N–H bond of ammonia that transfers a proton to the pyridine following oxidation by the attached ferrocenium moiety in a proton-coupled electron transfer (PCET) step. This generates an amidyl ( • NH 2 ) radical stabilized via H-bonding to a pendant pyridinium moiety that rapidly dimerizes to hydrazine (H 2 N–NH 2 ), which is easily oxidized to nitrogen (N 2 ) at the glassy carbon working electrode. This report identifies a general strategy to oxidize ammonia via H-bonding to a base (B:), thereby activating [B···H-NH 2 ] toward PCET by a proximal oxidant to form [BH···NH 2 ] +/• radical cations, which are susceptible to dimerization to form easily oxidized hydrazine.

Topics & Concepts

ChemistryAmmoniaElectrochemistryOrganic chemistryInorganic chemistryPolymer chemistryElectrodePhysical chemistryAmmonia Synthesis and Nitrogen ReductionAdvanced Photocatalysis TechniquesRadical Photochemical Reactions
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