The effects of diet composition and chronic obesity on muscle growth and function
Luís Gustavo Oliveira de Sousa, Andrea G. Marshall, Jennifer Norman, Jordan D. Fuqua, Vitor A. Lira, John C. Rutledge, Sue C. Bodine
Abstract
The effects of diet-induced obesity on skeletal muscle mass are complex and dependent on diet composition and diet duration. The present study results show that chronic exposure to high levels of fatty acids does not affect muscle mass, contractile function, or protein synthesis in obese C57BL/6 mice compared with the consumption of chow. Obesity did result in a delay in load-induced growth; however, only a 45% HFD resulted in attenuated growth following 30 days of functional overload.
Topics & Concepts
Internal medicineEndocrinologyInsulin resistanceSkeletal muscleIsometric exerciseMuscle atrophyDiet-induced obeseBiologyObesityMuscle hypertrophyInsulinMedicineMuscle metabolism and nutritionMuscle Physiology and DisordersAdipose Tissue and Metabolism