Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors
Roberta Bivacqua, Marilia Barreca, Virginia Spanò, Maria Valeria Raimondi, Isabella Romeo, Stefano Alcaro, Graciela Andreï, Paola Barraja, Alessandra Montalbano
Abstract
Viruses have been recognized as the etiological agents responsible for many pathological conditions ranging from asymptomatic infections to serious diseases, even leading to death. For this reason, many efforts have been made to identify selective viral targets with the aim of developing efficient therapeutic strategies, devoid of drug-resistance issues. Considering their crucial role in the viral life cycle, polymerases are very attractive targets. Among the classes of compounds explored as viral polymerases inhibitors, here we present an overview of non-nucleoside triazole-based compounds identified in the last fifteen years. Furthermore, the structure-activity relationships (SAR) of the different chemical entities are described in order to highlight the key chemical features required for the development of effective antiviral agents.