<i>In vivo</i> stability of <sup>211</sup>At-radiopharmaceuticals: on the impact of halogen bond formation
Thibault Yssartier, Lu Liu, Sylvain Pardoue, Jean‐Yves Le Questel, François Guérard, Gilles Montavon, Nicolas Galland
Abstract
stability of SAGMB conjugates compared with those of SAB. The impact of astatine's ability to form XB interactions on radiopharmaceutical degradation may not be limited to the case of aryl radiolabeling.
Topics & Concepts
ChemistryHalogenationIn vivoCombinatorial chemistryHalogen bondArylDissociation (chemistry)CysteineHalogenStereochemistryRadiochemistryEnzymeBiochemistryOrganic chemistryBiotechnologyAlkylBiologyRadiopharmaceutical Chemistry and ApplicationsCrystallography and molecular interactionsMedical Imaging Techniques and Applications