Analysis of laboratory parameters in patients with COVID-19: Experiences from a pandemic hospital
Serdar Özdemir, Serkan Emre Eroğlu, Abdullah Algın, Hatice Şeyma Akça, Abuzer Özkan, Emin Pala, Mehtap Aydın, Gökhan Aksel
Abstract
Aim: This study aimed to determine the analysis of the laboratory parameters in patients infected with SARS-CoV-2 during the early pandemic period in Turkey.Material and Methods : This retrospective descriptive study was conducted at a pandemic hospital.All hospitalized patients and outpatients with a positive RT-PCR assay for SARS-CoV-2 were included in the study.Demographics, clinical characteristics, vital parameters on admission, laboratory findings, and drugs used for SARS-CoV-2 infection were obtained from the computer-based patient data system of the hospital and analyzed.The primary outcome of the study was the laboratory parameters of patients with COVID-19.The secondary outcome was 30-day all-cause mortality following emergency department admission.Results: A total of 2,012 patients were included in study.The rates of hospitalization and 30-day mortality were 24% and 2%, respectively.The most common symptom was cough, and the most common comorbidity was hypertension.The neutrophil count, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio values were elevated in the non-survivor group compared to the survivor group (P = 0.001, P < 0.001, and P = 0.020, respectively).The lymphocyte and platelet counts were elevated in the survivor group compared to the non-survivor group (P = 0.001 and P < 0.001, respectively).As predictors of mortality, the cut-off value for the neutrophil, lymphocyte and platelet counts, and the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were 5. 68, 1.42, 195, 3.09, and 141.8, respectively, and the AUC was determined as 0.704, 0.714, 0.727, 0.745, and 0.610, respectively (P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.023, respectively).Discussion: The results of the study demonstrated that the neutrophil count, lymphocyte count, platelet count, neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio are useful in determining prognosis in SARS-CoV-2 infection.