Artificial enzymes with multiple active sites
José M. Palomo
Abstract
Artificial enzymes based on the modification of a protein structure for the creation of new active catalytic sites have experienced a great boom in recent years. Multidisciplinary strategies of genetic engineering, chemical or chemical biological tools have been successfully described to synthetize them. However, a challenge has been focused on the creating of artificial enzymes with more than one active site. This could represent a new direction in the application of enzymatic tools in sustainable chemistry. Actually, only a few technologies have been described for designing artificial enzymes with two or multiple active sites. This review article underlines these most significant advances.
Topics & Concepts
Active siteArtificial enzymeEnzymeBoomMultidisciplinary approachProtein engineeringBiochemical engineeringNanotechnologyChemistryComputational biologyComputer scienceEngineeringBiologyBiochemistryMaterials sciencePolitical scienceEnvironmental engineeringLawCyclopropane Reaction MechanismsEnzyme Catalysis and ImmobilizationChemical Synthesis and Analysis